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Main Sequence

Main Sequence

Venture capital fund
·
Sydney

About

Main Sequence is a Sydney-based venture capital fund, founded in 2017, investing from pre-seed and seed through to Series A and Series B and beyond. Its recent deals span climate and energy, hardware and robotics, space and defence and AI infrastructure, and it spun out of CSIRO, Australia's national science agency, raising a $450 million third fund in 2022. Recent investments include Kinoxis Therapeutics and Avarni.

Written and verified by Cut Through Venture.

October 7, 2026

At a glance

Fund type
Venture capital fund
Headquarters
Sydney
Primary stage
Angel / Pre-Seed

Example portfolio companies

Metacognition Kinoxis Therapeutics Zabidou Facet Amtech Avarni

Source, Cut Through Venture deal tracker.

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